Agents capable of whitening teeth were initially discovered in the 1940s and were introduced into the mainstream market in the 1980s due to an increased interest in esthetics and a desire by individuals to have whiter teeth. The options for tooth whitening are numerous, with whiting products available as gels, strips, rinses, gums, dentifrice, and paint-on liquids. This Quality Resource Guide, directed to dentists, dental hygienists, dental therapists, and all office support personnel, provides an evidence-based review of methods and materials designed to whiten teeth. It describes the mechanisms for tooth whitening, discusses options and the effectiveness and safety of whitening modalities, and examines issues patients should understand when considering whitening treatment. Dental professionals are critical in effective, safe tooth whitening, and counseling patients about their options. This QRG will serve as an essential resource for all dental office team members as they strive to provide maximal assistance for individuals exploring options for whitening their teeth.