Human Papilloma Virus (HPV) has emerged as a significant risk factor and is changing the epidemiology of oral cancer that occurs in the oropharynx. Since 1988, the prevalence of oral cancers associated with the traditional risk factors of smoking and drinking alcohol has decreased by 50% whereas the prevalence of those in the oropharynx associated with HPV infection has increased by 225%. It is estimated that over 50% of all oral cancers will be HPV-related by 2030. This Quality Resource Guide (QRG) discusses the epidemiology, prevention, and dental considerations for HPV-associated oral cancer. It describes the principles of a thorough exam necessary to discover HIV-associated pharyngeal cancer, and appropriate referral if warranted. The dental team&rsquo\;s role in the education of young men and women, and their parents, about HPV infection and preventive vaccines is also covered. Detailed tables will serve as a quick reference for the dentist when evaluating suspicious symptoms occurring in the oropharynx and for the dental team when discussing HPV vaccination with patients and parents. This QRG will serve as an important resource for the dentist, and members of the office staff, as they assist with management of this rapidly increasing oral health dilemma.