Biologic and social determinants impact differences in health expression in males and females. This evidence-based Quality Resource Guide (QRG) focuses on women&rsquo\;s unique oral health and general health issues that require consideration when assessing oral health and providing oral health care to women across the adult life-span. The QRG discusses: oral health and systemic health issues important to the dental care of women\; evidence-based dental practice protocols for women across the life span\; best practices for dental care of women\; and the impact of systemic disease on the oral health of women. Concise narrative discussions and well-organized tables present guidelines and approaches for evaluating and managing the oral health of women at all stages of life. This QRG will serve as an important resource for the dentist, and all members of the office staff, as they assess and provide therapy for women within the practice.