The key to a health care professional&rsquo\;s success when managing TMD is determining an accurate and complete diagnosis. Critical causative and maintaining factors must be identified and addressed in a case-specific plan of care. The cornerstone of any management protocol is patient education. Since the most common reason for the compromise of this orthopedic system is overload or excessive mechanical stress, the patient must participate in the management by conscious avoidance of activities which may aggravate the condition. Typically, treatment will include physical, pharmacologic, and behavior management strategies. Altering the consistency of foods, limiting opening, using moist heat and/or ice, as well as avoidance of clenching/grinding the teeth is extremely beneficial. Generally, mild pain relievers such as acetaminophen, non-steroidal anti-inflammatory medications, or aspirin provide appropriate relief. Muscle relaxants and sleep aid medications may also enhance treatment outcomes in select cases. This Quality Resource Guide (QRG), using an evidence-based approach, reviews the primary types of intraoral appliances available to provide therapy for the patient with TMD, outlines the pros and cons of each approach and discusses the issues that must be assessed when implementing a course of therapy. It is expected that following study of this QRG, the reader will: understand the rationale for the utilization of various intraoral appliances\; recognize the multifaceted nature of TMD management with multi-disciplinary approaches\; appreciate the criteria for achieving an optimum treatment outcome with occlusal orthosis therapy\; and minimize complications that arise for the clinician when they use intraoral appliances. This QRG will serve as an important resource for the dentist, and all members of the office staff, as they assess and provide therapy for individuals demonstrating TMD.