Clear Aligner Therapy (CAT) has become very popular approach to orthodontics in the United States. Consumers are often bombarded by information regarding why CAT may be appropriate for their or their children&#39\;s dental condition and seek advice from their general dentist or the office staff. This Quality Resource Guide is designed to assist the general dentist&#39\;s office t0 appropriately addressing those questions. CAT was first used as a treatment option for mild to moderate malocclusions but has recently gained widespread acceptance for broader applications due to advancements in its use of digital technology, appliance customization, 3D printing, and biomaterial science. The QRG discusses the history and development of CAT, explains the effectiveness of CAT for treating mild to moderate malocclusions, discusses advancements in digital technology, 3D printing, and biomaterial science, compares and contrasts the benefits and potential drawbacks of clear aligner treatment for patients and providers, and identifies the potential risks and complications associated with direct-to-consumer (DTC) aligner treatments. A diagram and associated narrative outline the workflow for successful orthodontic care with aligners. This QRG will serve as an essential resource for all dental office team members as they strive to provide maximal assistance for individuals exploring options for orthodontic therapy.