Though scientific investigations link smoking with numerous chronic diseases including oral cancer and periodontal diseases, approximately 28.3 million individuals continue to smoke in the United States. Smoking creates a physical dependence upon nicotine coupled with psychological and behavioral dependences. This Quality Resource Guide (QRG) presents straightforward guidelines for the dental professional to determine the stage of a patient&rsquo\;s nicotine dependence. Based upon that assessment, the clinician is guided in ways they may assist the patient to create an appropriate withdrawal strategy, using the available behavioral and pharmacotherapeutic approaches. The sixth edition of this popular QRG provides several references, including Cochran Database of Systemic Reviews.