The U.S.Center for Disease Control Guidelines state that each dental office should assign at least one person as an infection control coordinator (ICC). The ICC should understand the modes of cross-contamination in dentistry, current infection prevention policies, products/equipment available to maintain staff and patient safety, and agencies' policies/guidelines that impact infection prevention and safety in dental practice. While the ICC is responsible for coordinating the infection prevention program, the entire dental team must be committed and accountable to comply with the office’s written infection control program. This Quality Resource Guide (QRG) discusses regulatory and advisory agencies that impact infection prevention in dentistry, the role and responsibilities of the infection control coordinator, the precautions needed to prevent disease transmission in the dental setting and provides current updates for infection prevention policies and protocols. This QRG will serve as an essential resource for the dental office ICC and all office team members during new staff members’ orientation, as well as periodic office updates regarding infection control.