Artificial intelligence (AI) is firmly embedded in society and influences how we work, shop, travel, communicate, and even make decisions. In healthcare, AI is being promoted as a tool to improve efficiency, accuracy, and quality of patient care. Integrating AI in dental practice may ultimately reshape how general dentists approach caries diagnosis and treatment planning. But how does AI stack up against traditional protocols? Using caries detection as a model, this QRG outlines essential considerations for the dentist to consider when contemplating incorporating AI programs into their practice.