Dentists always faced the challenge of making good decisions regarding the incorporation of new technology into their practice. Questions of reliability, relative effectiveness, predictability, effect on outcomes of care, and cost all need to be answered based on objective, non-biased assessments. The sixth edition of this Guide provides the practitioner information about newer diagnostic instruments including cone beam and digital imaging, electronic apex locators, rotary instrumentation, disinfection and root canal filling in a concise format. The newest science is reviewed with regard to instrumentation and filling materials. The extensive references provide the reader with the basis for the author’s evaluation of the various technologies. This Guide can serve as a fundamental resource for the practitioner initiating or expanding the delivery of endodontic therapy within their practice.